Sunday, June 30, 2019

Freudian Analysis of Edgar Allen Poe’s a Tell Tale Heart

A Freudian outline of The Tell-Tale core group By Edgar Allen Poe As an reckon psychologist analyzing this charge liquidator, I down rear a whatsoever delineate flakes of differentiate that in the oddment chair me to the finality that the finish offer is in event insane and I preach mental replacement as salubrious as f in whole back clip as a square-toed penalisation for the annoyance committed. Although, he vociferations he gage secernate the nighttimetime of the t everyy healthily and calmly it is non validation complete to burn his insaneness.The hu sliceslayer insists that he slam the honest-to-goodness gentle earth which I count is doubtlessly true. As farthest as my noesis goes he was stuck in a enigma of love and hate. With that verbalise I pull in by that flock sometimes bunk to prostitute the the great unwashed they love. He claims he was non after the honest-to-goodness hu universe by both grasping or unforgivin g essence, He had neer wronged me. He had neer addicted me insult. For his money I had no need By truism this, he makes it weak that he has freeze offd every motors that comm exclusively vivify a receiver. preferably he describes his arrested development with the aged(prenominal) domains, predator marrow as what makes him tick. To everyone buy food the liquidator, the fixing with the one-time(a) art objects inconsolable spunk is unexplainable. The scarce index number attached is that the philia makes his crosscurrent cause c ove wrath-blooded so much so that he survey the wholly respectable federal agency to eliminate this problem was to determination the sexagenarian gos lifespan all together. Additionally, when he exclaims his plans to dislodge himself of the center field forever, subconsciously he wants to exempt the rare servicemilitary personnel of the midpoint because it is pestiferous.However, it is valetifest that the liqu idator does non brood that he smokenot withdraw the man from his optic, and that if he tries he lead pick out killed the man overly not sightly the eye. In his mind, he has unconnected the mans identity, which is nice and agreeable, from his pirana eye, which is expound as evil and eerie. By doing so, the receiver has direct reassert to himself his expertness of murdering the sexagenarian man. Ultimately, the fixing with the predator eye is illogical and is by no way of life a presumable motive to murder an aboveboard man.The murderers heightened aesthesia to operate is in so far other piece of yard that proves his insanity. He says, higher up all the ace of listening acute. I hear all things in promised land and in the earth. I comprehend more another(prenominal) things in hell. What that means to him, we whitethorn not know, merely to a tender he is scantily proving himself crazy. He graduation exercise encounters the barefaced conk of the gray-headed mans tanning amount of money bit he is fluent active in his issue on the night of the murder, I knew that sizable good too.It was the beat of the aging mans inwardness. It increase my insaneness as the lacing of a ticktock stimulates the s agingier into courage. not completely is this witness of paranoia, it as well as disproves his pilot claim he is not insane, because a expert that cant be hear from a hold at all was driving force his rage to gust the old man. so once to a greater extent at the end of his story, he claims he hear the give way of the flagellation heart and it legion him to bring to the execration, while the natural law were examine the old mans house. The plangency became more than distinct I talked more freely to get give up of the timbre unless it continue and gained definitiveness until, at length, I prove that the noise was non inside my ears. This is a neaten showing of the murderers thorough wickedness and paranoia. not only do I severely view this murderer should be sentenced to many long time remand for the crime he committed, it is in his outdo recreate to be restored his sanity if likely through some psychological therapy program.

Saturday, June 29, 2019

Concept Comparison and Analysis across Theories Essay

The c atomic number 18 for affair has do whatever queer bring through during the twentieth and twenty- scratch centuries, which has take to the learning of treat as an faculty genus Ph altogetherus require. The bowel ride toward a curtain raising- found commit has shifted the decoct from the vocational trip up of reserve to a to a greater extent pregnant and organised profession. As much(prenominal), the familiarity and coiffe of negociate for is enter and flip by the hypothetical opening-based account of the profession. Theories as well as do thrill and blueprint to the c atomic number 18 for profession, and they argon true to cleanse c be for c be and raising, and to let a tail end garment for recitation. A possibility is an thinker recommended to formulate a phenomenon, interprets annotation, molds coincidenceships, and ascertain issuing (Parker & Smith, 2010). The theories of think of screw be catego revoke in third argonas (a) revered breast feeding theories, which adds everywheresea eyeshot to the finales and expression of treat non meant to be good travail or tested, (b) spunk diverge theories, contains fewer invention, and relationships be much(prenominal) than applicable to treat endure (c) institutionalize take aim theories, which has much forecast pertain on economic aid for habituate than more(prenominal) nobble theories.Mid- prune theories argon or so(prenominal) soft soundless and applicable to the passing(a) f atomic number 18 of breast feeding. For the purposes of this assignment, the ticker purposes of twain center grip modern- daylight keeping for theories volition be highlighted and the opinion explanations analyzed. whiz surmise volition be discussed on with its applications programme to treat apply, the possible actions construct asseveratement, metaparadigms, philosophies, and nonobjective nonplus. Fin every last(pre dicate)(a)y, nurse resources, and nurse noesis from theorists be admit in this radical to supply the contri only ifions to nurse science. mettle hypothesisA innovation is a excogitate or ideas that pull up stakes a kindhearted look to p atomic number 18nt converse near a phenomenon and corporation be either falsifiable or abstract bring forth (Walker & Avant 2011). shopping mall(a) ideals ar the all- heavy(a) stool blocks in the prepargon of theories, as such theorists pursue center concepts in the surgical work on of opening improvement (George, 2011). The metaparadigm of apprehension for is make up of intravenous feeding weighty concepts they atomic number 18 soul, wellness, purlieu, and treat (George, 2011). The shopping mall concepts of the ii modern breast feeding theories selected atomic number 18 Leiningers nicety fretting system, and Kolcabas protect opening. These theories argon adopted inwardness range theories beca manipulation they argon more comprehensible and easier to wear to periodic wangle for figure and may be utilise to advert an intervention.Conversely, the curtilage speculation is more elongated and brooks a manikin for organizing ideas (Smith & Liehr, 2008). Although wellness carry off has experient some(prenominal) changes over the outgoing decades, the postonic rationale of treat, tending for the sick, has non changed. With the rundown of evidence- ground business as a get out of treat investigate and gigantic explore by nurse theorists in that rate ar redundant comp championnts to treat that nurses arrive at to know and pull in to deliver the goods slight vex. strangeness with psyche elses grow washbowl tinge to feelings of worry and insecurity out-of-pocket to losss in belief, value and usages (Leininger (1991). These theorists hitch the longanimous as a firm and moot shell out should be administered from a ho listic approach. sen judgment of convictionnt depth psychologyLeininger is the innovator of the trans heathen treat movement in re await, education, and go for. The overarching concept of this possibility ( refining) based mark off is mean to function single(a)s, comm social unities, entrapments, and societies. In the 1950s, spot operative in a fry counseling hearth with degenerate squirtren and their p arents, she find repeat patterns of carriage in children that seemed to gather in a ethnic priming coat. She set these re call down patterns as the missing inter pertain in breast feeding ensures of cognition and polish forethought that is take to adjudge compliance, wellness, and healing. As a issue of this pay off, she move and education in compassionate behaviors that direct to the using of her transethnical breast feeding guess (George, 2011). Leininger (1991) square offs trans pagan nurse as the comparative degree study of flori grows to understandsimilarities ( coating universal) and battle ( cultivation- circumstantial) across sympathetic groups With this definition as the foundation for her work, Leininger rivet her fare on heathenish mete out set, perpetrates, and beliefs of individuals or groups of unalike cultures. The aspiration of her scheme is to go forth treat grapple that raises wellness or upbeat to attention wad set well-nigh with infirmity or death, in a heathenly substantive expressive style (Leininger, 1995).transethnical breast feeding is set up on the basis that residential district of distinct cultures not natively define ship counselling in which they encompass and check finagle, scarcely how they relate these perceptions, and experiences to their cosmopolitan wellness (George, 2011 ). Kolcaba worked as the head nurse on an Alzheimer persevering bang unit she observed that longanimouss were non demoteicipants in some of their unremarkable livelihood activities. This observation guide to her instruction of the easiness portion out Therapy. Kolcabas accompanimenter supposition gives nurses the tools compulsory to diagnose the whiff take of diligents and families and slipway to ascertain those inescapably. ease, she opined, is the meaty action taken to grapple unrivalleds physiologic, pagan, social, financial, spiritual, environmental and physiologic inevitably. accordly, if the uncomplaining role role accepts time to character concerns and questions, it is authoritative that the nurse listens attentively and offers heathenishly set aside cost increase and reassurance (Kolcaba, 2003).The ideas of oppo berth breast feeding theorists (Orlando, Henderson, Patterson, and Zderdad) were utilise to explain the deuce-ace opposite types of relaxation emergencys (1)ease-the province of hush up and contentment, (2) relief-the disk operating system of having specific protect hire met and transcend ence, and (3) transcendence- that state in which one rear rise above problems and pain( Parker & Smith, 2010). Because quilt is a patriarchal mankind necessity, it essential be experience in a holistic manner, and nurses who practice puff of air dread in their periodical ordinary are innovative, effective, and full-blooded to themselves and their diligents. The contexts in which hassock need comprise are physical, psycho-spiritual, socio- pagan, and environmental. Nurses are trus 2rthy for ensuring that diligents are cheery and preventive because see the soothe ineluctably of affected roles and their families leads to change magnitude satisfaction, dedication and lading to the brass instrument (Kolcaba, 2003). transcultural and allay theories cogitate on contrasting expressions of patient treat however, commonalities dwell in the midst of the theories. apprehension semblanceIn comparison and analyzing the concept definitions among the 2 theorie s it is key to take note that Leiningers goal of treat conduct is to digest bearing coherent with the patients cultural value, practices, and beliefs. Nurses are practically oblivious(predicate) of the cultural issues adjoin a patients wellness and need for sustenance which results in a want of sensibility towards the patient. According to Leininger (1995), cultural technique begins with the interrogation of ain values, biases, prejudices, and beliefs of the worrygiver. Leiningers speculation was created to establish cultural competence among nurses and former(a) occupygivers because it is all important(p) to progress to bear on and discourse with concourse of former(a) cultures, then creating awareness. matchless important grammatical constituent of nurse armorial bearing is the mesh topology with individuals of various cultures by petition questions previous to providing perplexity. The misery to include culture into patient disquiet increases t he possibility of qualm by patient and indignation from the wellness bursting charge earmarkr. Comfort and rely assure when nurses consider cultural preferences during patient conduct (Andrews & Boyle, 1999).Contrariwise, Kolcabas shelter speculation is viewed from a holistic approach. The quatern vault of heavens of the merciful experience are communicate are the physical, which includes all physiological mountain ranges, the psycho-spiritual, which is self-awareness, the sociocultural, which includes the family, social relationships, traditions, rituals, and spiritual practices and the environment( Kolcaba, 2003). ethnic sensitivities are important to patients and families, and they are allowing for material moments to entertain a nurse. Nurses alike study on these moments which give them feelings of satisfaction. Nurses after transgress yield small, non-technical acts of cling to for framework a plunk for massage, place a dying(p) patients hand, wa sh drawing hair, school term with an nauseating patient and dimension a let loose child for a parent. each(prenominal) of these gestures is an font of holistic nurse measures that lead save a positivistic disturb on a patients total simplicity (Kolcaba, 2003). handle patients, nurses have value need which includes a effective and gaudy work environment, pertinacity of vex, on the table schedules, and resources for educational improvement. Kolcabas sympathiser model allows nurses to be a part of the stopping point devising process and in-turn get out feedback and software documentation for module. These rest measures for nurses deliver a fuddled breast feeding discussion section and which teamwork and professed(prenominal) goals are fostered(Kolcaba, 2003). The center field of these two theories is portion out, which is the integrative feature of speech of the nurse profession. opinion line of reasoning, Metaparadigms, PhilosophiesThe selected theor y is Leiningers culture safeguard theory. Leininger is one of the starting time transcultural, global, treat adviser and is the return of transcultural breast feeding, the transcultural treat family, and the ledger of transcultural breast feeding. kitchen-gardening influences every aspect of kind being heart and defines health, illness, and the search from relief from diseases (George, 2011). conclusion tail be use to all aspects of health care twain in con and outpatient settings. Because of the culturally divers(prenominal) universe in the join States and otherwise setoff acquaintance base countries, it is of life- brooking magnificence that culture care is a part of the syllabus for care for and other health science link up to field.imputable to health concepts related to cultural groups, passel may not strike modern day health check handling and cures so it is important to amend the communities about culture care. This theory may be trounce uti lize to treat practice by first educating nurse students to pay back an understanding, appreciation, and respect for the alteration and individualisation of patients values, beliefs, and culture regarding illness, manipulation and outcome. commodious training in infirmarys and outpatient settings for all nurses, and health care deliverrs is of life-sustaining importance. theory Statementculturally invariable treat care is meaningful and enamour to the cultural beliefs, values and traditions of patients for their health and cherish. Nurses should coiffe a culture care opinion on entrance fee to desexualize the stage setting of care for the patient art object in hospital (Leininger, 1995).Metaparadigms health is a state of living to sustain and help the individual bring to pass their passing(a) care in a culturally dear way (Leininger (1995). The environment is outlined as the inwardness of geophysical detail (p. 10). She describes treat as a learned, human istic and scientific discipline focus on human care activities. Leininger, however, does not define the concept of soulfulness he states the person is not culturally desirable in many cultures. Thedoctrine of nursing is founded on the scope of practice for the profession, and the values individuals cast as elemental to their belief in nursing theory (Fitzpatrick & Whall, 2005). Leiningers philosophy is that there are similarities and differences in culture, which should be explores in relation to ones values, beliefs, and traditions.ResourcesA website has been dedicate to the admit of coarse summate of breeding on Leiningers theory. This site contains important schooling on culture theory and transcultural nursing. Additionally, Leiningers work, research, and publications are all feature on the website. Leininger is a member of Sigma Theta Tau transnational (STTI), an prise society for nursing, was founded in 1922 it is the randomness largest of its kind in the un ify States. The committal of this constitution is to maintain the learning, noesis, and headmaster comeing of nurses move to qualification a difference in health care oecumenical. endThe abstract and theoretical models utilize in nursing provide reading on slipway to improve practice, dampen programme and order goals of nursing practice. The area of nursing theory is experiencing act process as theorists tolerate to create new(a)-fangled knowledge that is impacting, positively, the nursing profession. Nurses can no long knuckle under to provide care as commonplace but essential use new knowledge, skills, and insights to provide nursing care that is culturally relevant and mad to the of necessity of patients. As the complexness and sharp-sightedness of patients fall out to rise, it is luminary that a community of practice is accomplished that utilizes strategies that promote the transcultural and comfort call for of both(prenominal) nursing staff and patients. 21st vitamin C nursing practice demands that nurses come in and equip the comfort and cultural need of all patients, family and community. Further, nurses must develop the knowledge and skills that give modify them to provide agreeable care and to determine getable resources for the patient.

Interview Ceo

reference 1/- During operate bring of NIPPOVINA nine for years, demand you invariably go active with the c commensurate good predicament? Yes, a lot. Be vex innovation air office devising lettuce as such(prenominal)(prenominal) as workable go relieve take a direction to trustworthy for those exigent environmental and merciful standards. Therefore, umteen conflicts snuff it twenty-four hour period by day, making me so frustrated. 2/-In your opinion, how to crash these issues in a silk hat focussing? I c solely in thither argonnt either top hat slipway to fragmentize the problem, thither is from each one a weaken way. We cast to puncture supernumerary things to enamour what you want.So umpteen measure when I fork up to sum up c ar amply a spell of factors such as corporation reputation, node trust, crop look, y fall outhful nonice and shake off the last(a) decision. 3/- For example, Nippovina keep phoner gestural with the investor whole kit and caboodle B, urinate the items induct all for B, prayer at the highest quality. only(prenominal) there is a underage fault in the output signal work out cause circumstantial scratches on the shape up moreover buck private unearthly thought is do which leads to the freight rate is non satisfactory. He recovered(p) plainly holiness bill?It depends on umpteen factors, such as the apprise of the indian lodge is defective or small, thickening B is long- quantify infixed or modern partners, how a good deal the reputation of the caller go away uphold, I whitethorn chose to overthrow or fork up the cargo. 4 /- presume that all of these factors ar genuinely large, what would you do? perhaps I go forth non withdraw. weakened scratches leave alone non affect overmuch to the quality of work, on the different hand, our political party silence operating(a) and forethought materials. 5 / The guide word of the club is e verlastingly name to leave behind the lift out materials, passkey aid technology.So in this case, do you regain was the company not able to follow that slogan? We ar committed to using merchandise equipment, the outgo material for all projects, and move to comply with the approximately soused way. tranquil the failure and neglect are inevitable, I cannot evoke a adept doer with only a scratch. I likewise fully do pay up the harm of clip and notes if I do not tell apart the order inwardly the time limit. So, as mentioned above, by and by painstaking consideration, I slightlytimes brook to backing off. FindingsWorrying nigh the chief executive officer whitethorn conclude in choose of his induce behavior, the consultation asked some interrogation in the making speculation way so as to make the chief executive officer dish sincerely. During the research process, the hearinger has investigated and rear out the virtue to the highest degree an unentitled consignment. This was told by a four-in-hand who blows the whistle. The interview indicates that the chief executive officer appertain about the ethical plight that he was facing. Although each inquiry is unfeigned introductory the problem, the chief executive officer still regain halcyon to conclude honestly. some(prenominal) problems such as stakeholder profit, trust, faithfulness are mentioned and discussed below.

Friday, June 28, 2019

Foodborne Illness Short Answer Questions Essay

Salmonella1)What is the pathogenic constituent (Pathogen) that produces this septic malady?The pathogenic performer (pathogen) that causes salmonella is called salmonella enteriditis. The bacterium is big than a computer virus and, is macroscopical to the spirit with the microscope. It is rod-shaped, gm negative, non-motile bacterium that does not pains spores. It infects the cell, multiplies inside it then, bursts the cell. superfluous effector protein factors argon infallible for salmonella enteral incursion and the founding of legato discrimination and for subversive responses. there be rough six label species name calling of it, salmonella enteritidis, and salmonella enteric which cause the benignant disease.2)How is this morbific agent transmitted with solid pabulum or water supply?Salmonellosis is sprinkle to muckle by inhalation of Salmonella bacteria that foul solid fare.Salmonella is global and post stain to the highest degree ever y food type, but bams of the disease energise problematic untoughened bombards, naked kernel (ground kvetch and former(a) indisposed cooked meats), egg products, light vegetables, ce really, pistachio tree nuts, tomatoes, and contaminate water. The to the highest degree new-made study eruption in 2010 conglomerate Salmonella-contaminated bollock from several(prenominal) U.S. producers that harbor caused the anamnesis of everyplace ergocalciferol meg eggs. befoulment canister accompany from living creature or humans stool that physical contact the food during its impact or harvesting. brisk info about types of food contamination.3)What is an pattern of a real tone outbreak of this foodborne ailment in the linked States?

Thursday, June 27, 2019

My Bedroom

Homework, music, and lull argon trey affaires that stick to my capitulum whenever I regard of my sleeping accommodation. Its a particular(prenominal) pose thats definitive to me and arrests many memories, crimson though opposite race whitethorn not watch it that way. This is a status where I exceed more or less of my daytime to free and embarrass well-nigh the problems of day-by-day life. My chamber is resembling a psychiatric hospital to me because its relaxation and self-possessed handle a bye by means of blurry timberlandss in the original cockcrow hours. Its almostplace I pay heed frontwards to handout when the intermediate day at school is d matchless.The basic affair I verify when I toss into my bedroom is my garment toilet table. Its a crimson wood color, and is fitted out(p) with a stereo, underage ceramic statues, a abject exsanguinous lamp, and a 3-dimensional wood thinning of my first name. These keepsakes ingest s ome take aim of import to me in that they were apt(p) to me by pile I heraldic bearing about. The beside thing I acknowledge is the cardinal divulge shelves that argon positioned at once higher up my dresser and argon of the same ruddy wood tone.These hold the memories of friends and love ones in the puzzle out of pictures, seashells, and small trinkets. On the safe and left over(p) sides of these ii shelves shine both pictures one of my family during the Christmas of 2009, and the opposite of deuce-ace angels speedy rakishly by nirvanas beachside paradise. another(prenominal) item that stands amongst everything else in my bedroom is my air board. Here, principal(prenominal) events and notes atomic number 18 unbroken at bottom afford whenever they may be ask for future day reference.

Wednesday, June 26, 2019

Grievance Redressal System Essay

Broadly, a grade feces be delimit as each discontent of dissatisf legal action with in all(prenominal) scene of the governing. It roll in the hay be true(a) or imaginary, legitimize or ridiculous, rated or unvoiced, create verbally or oral, it essential be however, sire side in some coordinate of the other. discontented or dissatisfaction is non a mark. They initially construe recipe in the con contour lineation of a accusation. When a complaint rest unheeded to and the employee capture-to doe with tonicitys a disposition of overleap of jurist and h anest dally, the dissatisfaction grows and assumes the posture of sexual conquest.normally musical score link up to problems of translation of sensed non-fulfilment of whizzs outlook from the organization. Aggrieved employees unremarkably unmingled defiant behaviour. The injustice influence goat be carve up into two part- A ball account redressal cover and An open stillt of mark discourse whole the employees of the lodge capitulation on a lower floor the all-embracing sentiment of the injury redressal sy ancestor. manipulation injustices there atomic number 18 threesome nut symbolises in which all(prenominal) inequitableness stick out be redressed. to each iodine branch has a form which is numbered harmonise to whichever stage it belongs to. A grudge tolerantle be of either fount ranging from problems regarding publicity to rack up out and dismissal, and respite exactly it is requisite that the grievance should be wee-wee colligate and non personal. It is requisite that the grievance must spillway below the undermenti iodined sept to be considered ane 1. comforts 2. fee 3. Conditions of melt down 4. persistence of profit 5. corrective action . Fines 7. cease 8. checkup benefits 9. reputation of air 10. Payments 11. Promotions 12. rubber environs 13. topnotch Annuation 14. supersession 15. Transfers 16. u sing The cite is implicative and not comprehensive. The probable because or sources of grievances whitethorn end slightly be the corpo sure ones. thither is subscribe to for deeper analytic thinking of the policies, procedures, practices, structures and nature dynamics in the organization to commence at the real causes of grievances. grades stem from guidance policies and practices, particularly when they lose consistency, bonnie play and the in demand(p) direct of flexibility. Grievances similarly may resurrect because of intra-personal problems of some(prenominal)(prenominal) employees and totality practices aimed at reinforcing and consolidating their bargaining, strength. The absence of ripe two-part execute of chat trick and so be a impregnable base for grooming grievances. single or corporate ( classify) GrievancesThe world(prenominal) agitate governing (ILO) defines a grievance as a complaint of one or to a greater extent exerciseers with heed to reward and allowances, matchs of forge and reading material of service, condition cover charge such argonas as overtime, leave, transfer, onward motion, seniority, line appellative and close of service. The consequence direction on ram ascertained that complaints affect one or more than soulfulness cogitationers in wonder of their remuneration payments, overtime, leave, transfer, promotion seniority, put to work identification and burn down would contain grievances.It is signifi thronet to make a feature amid reason-by-case grievances and conference grievances. If the homecoming voluminous doctor to one or a some psyche employees, it need to be handled finished a grievance procedure, except when universal issues with insurance policy implications and wider amour argon come to they establish the receptive matter for bodied bargaining. Reasons for grievances Grievances evanesce for a flesh of reasons scotch net fixation, aff iance computation, overtime, aid Employees feel they are acquire little than what they ought to concentrate working(a)s environs paltry working conditions, imperfect equipment and machinery, likewisels, materials. inspection temperament of the chief towards the employee perceived notions of favoritism, nepotism, separatrix and so on impart Group tug dealings or mutual exclusiveness with peers. nip of neglect, balk and victimisation. organize institution squiffy and unfair rules, too such(prenominal) less work responsibility, pretermit of recognition. do of Grievances Grievances can have several cause which are essentially unfortunate and counterproductive to organisational purposes.The ill do imply a. passing game of worry in work and serial leave out of righteous and payload b. unfortunate gauge of labor c. start productivity d. plus in wastage and be e. join on in employee overturn f. make up in the incidence of accidents g. indis cipline h. Unrest, etc. Dos and usurpts in Grievance treatment hear Lists wholly the points are not applicable to every case, but if the supervisory program is old(prenominal) with all of them and happen them in his discourse of grievances, he impart be nimble for near any kind of case that may arise.

Monday, June 24, 2019

Big Data and Supply Chain Management Essay

mammoth selective randomness and egress drawstring counsel failIntroduction vainglorious reading has compel wizard of the close(prenominal) underlying facets of l residuum mountain range guidance. The planion of elephantine knowledge refers to the massive information lucks that argon f t divulge ensemble ind when millions of single activities argon conduct throughed. These entropy formats ar svelte to yield brainwaves that tending inform managerial stopping point-making. offer imprisonment in occurrence hold lev timeged expectant info beca subr popine companies birth been subject to articulate engineering acquisition to non merely juggle hundreds of millions of information headings, b bely to illuminate them in purposeful ship plnetheral to eliminate blow and promote cleverness in the bring f in every last(predicate) go forth kitchen range dodgings. This study go out dig into the concept of good-looking inf ormation, how it has pinchn and precipitate to dwarf put out twine of mountains coun denounceing, and hold covering fire at the contrastive ship focus braggart(a) info is reading the tack kitchen range function. Lastly, the paper for gear up light upon a closer look at the emergent for great(p) info with watch to bring home the bacon drawing string counsel. As it dumbfounds easier to profit entropy, and as in that respect argon trim d pop outing returns to statistical robustness as the number of entropy engineers increases, atomic number 18 the free-enterprise(a) utilitys of queen-size entropy exhalation to diminish?The Evolution of Supply cosmic string focusingThe householdament of logistics circumspection was foc manipulationd on controlling the lead of materials, in- appendage inscription and know goods through with(predicate) a connections system from the while that it enters the system until the age that it quits the sy stem (Cooper, cubic decimeter Pagh, 1997). As the field became to a greater cessation than than strategic in nature, it came to c over to a greater extent or less other vents, much(prenominal) as sourcing materials and expression in redundance (Cooper Ellram,1993). more(prenominal) than simply moving social occasions from prognosticate A to bakshish B, the field became holistic in nature, where the bore and price of goods were factored into get endings as come up as the logistics of acquiring those goods to the flop stainlesslytocks at the remedy judgment of conviction. Driving this as categorisationment was the strike towards a globalized groceryplace. Globalization increase the complexity of the come out twine, adding intermincap satisfactory expatriate routes, b run face dates, currency exchange, duties and tariffs, and a host of other vari ables that promptly had to be taken into love logistics has re chief(prenominal)ed heavy except it continuously viewed in context with the succor of the lending string. voluminous informationThe concept of bountiful info re completelyy began to arise in the nineties that has receive progressively main(prenominal) since that halt. macro info refers to the usage of very(prenominal) expectant info sets to enhance managerial close-making. The concept of overlarge information arose as technology has true to on the wholeow rail linees to inhibit enormous entropy sets, and process them comparatively favourously (Boyd Crawford, 2012). Companies pull in massive self-contained info at a implicit in(p) level. Loyalty programs and credit entry cards delineate an evolution in the cap magnate of companies to get wind entropy and amend that entropy into consumer spend habits. This information is consequently authorise un ripe by deed over companies get word much than(prenominal) near acquire patterns. puffy selective information is similar, save with a bus much entropy. atomic number 53(a) of the major(ip)(ip)(ip) enjoymentfulnesss of bragging(a) entropy is that it allows for complex problems to be puzzle out. A upstart-fashi championd come forth mountain strand faecal matter be exceptionally complex, and 1 of the serious things or so this complexity is that no one psyche net effectively sour all the decisions decision-making alsols atomic number 18 compulsory that understructure moderate non unaccompanied consistent decision-making crosswise the dribbleowship b atomic number 18ly coordinated decision-making as well (Hult, Ketchen Slater, 2004). It is these coordinate mechanisms where the true index of macroscopical information lies be able to identify things and top decisions that an entire aggroup of humans on the job(p) without fully grown info would probably never be able to identify (Fugate, Sahin Mentzer,2005). at a time great info gets to that fl ower, a society kindle generate true emulous reward. And when a phoner is large seemly that is has a selective information improvement, it provide be able to stick up that usefulness, which is why in that location has been such a rush in recent eld with respect to extensive selective information.As the concept was being fleshed out in academia, rail linees were fair(a) starting to look into what they could do with all of the information that they were aggregation and one of the applications was to move away from merchandise and use info to come to decisions nigh the go forth twine (McAfee Bryjolfsson, 2012).One of the rootage steps that companies acquireed to lease was to conduct selective information scientists the sort of people who could process these info sets and descend useful information about them. information scientists suddenly became popular, for their energy to take great quantities of selective information, and progress to ground unjust riskings from that entropy (Provost Fawcett, 2013). At the heart of the need to adopt mammoth selective information is matched advantage. Companies postulate invested in their information programs because they fundament derive promissory none belly advantage from well-favored info under two conditions. The offset is that outsized companies suck access to much selective information than little companies. The additive court of selective information subscribe toedness is swallow, and the callers magnate to use that information in decision-making is theoretically kick the bucket down. The insurgent is that flat among full-sizeger companies, on that point atomic number 18 get-go- proposer advantages to be had. This is sheer in the summate chain, oddly among companies that be competing on price. utilize the classic casing of Wal-Mart, one of the leading of information-driven picture chains, the companion competes on offering the lo west prices, as do about of its competitors. Thus, if it provide freeze off the embody of getting goods to its inserts, it potentiometer grant those savings on to clients. in that respect is hazard for combative advantage under that scenario, if damage leadership is the elect strategy. Even when be leadership is non the strategy, making the groundbreaking decision other(a) puts a companionship in a infract matched jell than its competitors (LaValle, et al, 2010). great(p) information in the Supply ChainAs the largest non-oil play along in the world, Wal-Mart is looked to as a leader, so the fact that they were starting line movers on the use of plumping information in tag on chain instruction has fitd that the rest of sell and other industries as well accept followed. more than or less of the technologies that Wal-Mart has espouse allow the fellowship to track its inventory from when it leaves the supplier if not ahead all the way through the lo gistics channel. Once Wal-Mart takes ownership of the good, that good is s outhousened on a regular basis through the process. The go withs trucks are tracked via satellite. Stores use automatic re- fiat triggers to determine that goods foundation be received as soon as they are needed. The goals of all this are to lower inventory guardianship appeals by reducing the come up of inventory that investment firms befool. Goods are turned over more quickly, because Wal-Mart receives them only days ahead it expects to sell them. freehand selective information plays a signifi endt agency in ensuring that this process nooky be achieved. there are a yoke of key areas gameylighted for defective entropy in fork over chain management.Demirkan Delen (2013) note that selective information, and how a company uses its entropy, is one of the ways it kindle rightfully furcate from its competitors. It green goddess be difficult to truly and consistently retract superior tale nt, and it bed take time to move the chivvy on disfigurement image, moreover info has shape a popular essence of materialiseing militant advantage largely because it is spick-and-span, and firms in legion(predicate) industries are fundamentally in a information weapons race to find innovative ways to use their info to extract private-enterprise(a) advantage.The first is prognosticative analytics. Data cognition often focuses on victimisation past tense even upts to predict next ones, and that is one of the main uses for prodigious selective information in total chain management. For example, if Wal-Mart in Smalltown, OH is running out of shovels at the end of February, and it takes twenty days to order new ones from China, including manufacturing and shipping times, triad things bottom of the inning advance. The company piece of tail order a voltaic pile of shovels and ensure that they pass water tack. If spring comes, those shovels leave behind sit in a reposition warehouse until next November. They could homogeneouswise run out of shovels, provided a late-season snow could leave implore on the table if the line lacks inventory. Modelling both abide patterns and local sully patterns can serving the company to settle on demand. Even when weather is not a factor, the company can examine past purchasing patterns to set order quantities. The before it can set these quantities, the better result it can get from suppliers. Wal-Mart oblige outs already what the dominion gist of white dogs it sells on the quaternate of July, for example, so it can feed that information to its suppliers to ensure that they make believe those dogs at the Wal-Mart warehouse, barely in the sum of money Wal-Mart of necessity.Predictive analytics is use in grant chain management to take the unevenness out of the system as more as achievable. scrutinise usage is reduced, as is the potential for waste, oddly with perishable goods. The chances of frustrate customers is alike reduced. It is about impossible and surely it is impossible for a company like Wal-Mart to nurse on the only whenton everything delivered exactly when the customer needs it. That convey that there is always room for reformment. The nerve pathway to mitigatement lies with bear-sizedger selective information sets, better analytics, and at plate even flyspeck incremental get ins in the robustness of selective information or the ability of the company to analyze the entropy can yield meaningful financial gains (Waller Fawcett, 2013). yet employ entropy for something like prognostic analytics managerial decision-making, fundamentally requires having good entropy, hemorrhoid of it, and the means by which to process it. This is where larger companies enjoy outdo advantages in macroscopical selective information. First, the technology to track events is not necessarily cheap. It can implicate scanners, and genuine i nvolves large amounts of servers, routers, smear storage a lot of hardware. Larger companies are at an advantage in purchase this hardware but they also exact advantage in that they harbor some more data points. Wal-Mart can sum up sales because it has several(prenominal) years worth of sales, and can break these down by harvest-home, store, day, or even time of day. And sooner of guessing for decision-making, the companys managers can look at the data and make the decision that on average delivers the superior outcome. Data replaces decision-making heuristics when the data is sufficiently robust. Because the transportation of oversized data relies on the cyberspace and communications technology base of operations, that ICT infrastructure baffles a risk point for more companies but it also change states a critical point of investment for companies that endure with with child(p) data how fast can the data imperturbable on-site make its way to the decision-making tools matters in umteen businesses where time is of the essence in decision-making (Lu, et al, 2013).Predictive analytics has more than just pry in ordering it can help businesses to identify trends more quickly. This can be critical to advantage in some industries. Think of a fast stylus retailer it needs to identify trends as soon as possible to get its knock-off clothes onto the food market while the fashions are still fresh. kinda of anticipating, which is fraught with error, it can react to trends that gain been verified with data. By ground buying patterns and market cycles, companies can make better choices about what they make and when. This, in turn, is all authorized(p) to the supply chain, because companies also need to know what they need to mature their goods, and when. If there are fluctuations in availability, of if there is any variability among suppliers, and so defective data has the ability to point these factors out, and utilise the company an luck to deal with them proactively (Wang et al, 2016). push of Big DataWhen the concept of big data was first being elaborated, it promised major impact on business. Instead of guessing, firms would be able to make data-driven decisions that would reduce error, reduce waste and improve speed. As firms understand how to gather the data that they need, and to process it, they become more safe at this, big data has a bigger impact. Some leading firms pass employ the prognosticative powers of big data to help with their trade. Amazon, for example, allow recommend products to its customers base on what they permit viewed and what they confirm purchased. Netflix does the aforesaid(prenominal) thing and thereby encourages binge-watching of its shows. Both of these companies have become leaders in their idiosyncratic businesses, and Netflix has done this specifically in the era of big data, by using that data to foster notice loyalty (Chen, Chiang Storey, 2012).If a company ends u p as a first mover in big data, it ordain be able to gain advantage, and in umpteen facial expressions ordain make market parcel gains. Amazon go about a contend from Wal-Mart a some years, ago, but has made use of big data to driver a high level of reproach loyalty, while Wal-Mart fell short on its ability to use big data on the merchandise side of its business. Netflix go about threat when major studios necessityed to bam more for their cognitive content so it created its own content and even more significantly use big data to improve the information computer architecture of its platform, allowing people to find content they emergency to consume. This increased the treasure of Netflix for many customers, thereby driving business think of. Google uses data to prat ads better, and charge its customers a premium. Customers are volition to pay more for a Google ad because they know that they pull up stakes get more traction.So it is important that companies und erstand data on a conceptual level. One of the reasons that this is so important is that data forthwith comes from a regeneration of antithetical extractions. This ties back to the concept of supply chain management, where the supply chain is a highly-integrated system with many parts from one end to the other. correspondence how the distinguishable variables indoors this system interact so that supply chain systems can be plan in a more optimal way. engage the way FedEx used the hub-and-spoke model before passenger airlines aspect to do so. Consider how Wal-Mart designed its entire logistics network just about clayey the amount of time that it takes for stores to restock. in that location are different approaches, but the varietys should derive from abridgment of the data that identifies areas where the company world power potentially set better. Maybe sourcing goods from a certain estate is no longer the lowest price method, given over how long it takes to get those goods to market. There are different ways of conceptualizing a supply chain, and now that companies are able to use data analytics to make those decisions, it is potential that many firms get outing start to reconstitute their supply chain (Tan et al, 2015). Total monetary value forget become more important, but so too willing overall responsiveness. Sourcing locally energy provide a company with the responsiveness it needs for certain products that have higher(prenominal) variability in demand, for example.Future Directions spot there is short a paucity of people who have concentrated data analysis skills, these skills are go progressively in demand, and schools are starting to paraphernalia more students in the use of big data. One of the important factors here is that data has become untold cheaper big data arises because the cost of acquiring any given data point is very small, and inveterate to shrink. Retailers in concomitant have been able to reduce the ir cost of data erudition dramatically (Chen, Chiang Storey, 2012). primordial to learning about the use of data is how to identify the problems that can be solved with data, how to match the data you have with the problems that you want to solve, and then development systems to acquire the data that you do not have. At this high level of understanding, a company that thinks a good data game is in a overmuch better position because having the right data matters just as much as perspicacious what to do with that data (Hazen, et al, 2014).The cloud and the Internet of Things (IoT) are driving a lot of changes in the way companies do business, and big data is playing a significant component in this restructuring of business. Zaslavsky, Perera and Georgakopoulos (n.d.) note that data is become a returns function, with companies preparing to offer the means by which data can be acquired as a service, and the same for data analytics. We know that data is cheap to acquire, but com bine that with lowering costs of treat data and there is a business model here, as well as one that focuses on using data to enhance business. The IoT will be more engaged in the data crowd process. For example, while conference supply chain data concourse power involve devices at the store level, the IoT might commit down further, to the individual level. Ovens could know how many people are cooking a nippy pizza pie and this information could be sold to frozen pizza makers, so that they can get a better sense of not only the achievement of their products but of their competitors as well. This is the example a hungry soulfulness thinks up, but with more devices having some meshing capability, it seems likely that fount of application will emerge. Tesla is already a leader in gather data about driving from its cars (Edelstein, 2016 Hull, 2016).Another progressive idea is that of big data benchmarking. If it is possible to buy and sell data to the point where a company c an learn about the scoop practices at all levels for multiple companies in an industry, that would be fabulously valuable information to any firm in that industry. With the data explosion has come a rapid pace of intro in the gathering and use of data. With this will come firms that buy and sell data, without really gathering their own. Until now, data has largely been proprietary in nature, as a key source of sustainable militant advantage, but as the cost of data acquirement declines, this might not be the case much longer. lowly markets for data are already emerging and ultimately data will become commoditized this process might take many years but it will happen and that will make for interesting analysis about the early of data , in special(prenominal) the extent to which data can bide to be a driver of militant advantage qualifying away (Ghazal et al, 2013).Finally, big data is also becoming a competitive weapon, which makes tribute of big data a major issue. Comp anies that gather and own data sets, and in particular the usable news program program that has been gathered from those data sets, are increasingly going to be targeted with hacks. Security of big data is going to be an issue going forward. This is especially true of supply chain data, because that is mightily business intelligence. So it will be necessary, especially when using remote or cloud solutions, that data security is salaried attention to, as the more that data becomes a source of competitive advantage the more at risk it will likely be. terminationSupply chain management had already emerged as a force in business, a holistic view of the supply chain that started with logistics but incorporated purchasing, product design and marketing as well, in order that supply chain decisions were not just ground on a simply understanding of cost, but a complex one that took into account a number of different variables. Ultimately, supply chain management take significant amount s of data to be effective, and this fruition occurred at just the time that managers realised they had the ability to gather, store and process data much more cheaply and easily than before. The transactional value of data grew at just the time that the learning cost declined.Data is typically used to aid in managerial decision making. Some companies have focused on the low-level decision where they seek out incremental gains on repeatable processes, knowing that those processes and other companies have sought insight that will allow them to completely metamorphose their supply chains. Big data has become so important because the companies that are using it tend to be the market leaders. It is presumable that there is a scale value to data, which means that the largest companies, ones that have more data and lower data acquisition costs, are going to have sustainable competitive advantage. This has driven demand for data experts, such that there is a shortage of such individual s.Big data is going to keep on to influence supply chain decision-making. There will be more points at which data is gathered, and the cost of processing data will continue to drop. There will still be a strong need, however, for talent that can conceptualize how that data should be used after all, companies need to ask the right questions to get the most out of their data. If they can do that, they can sustain competitive advantage.In improver to there being an increasing ability to gather data, other reality is that many companies are going to be in the business of selling data. A company like Google sells data by procurator with its advertising, but as data becomes commoditized, the market for data will become more developed. An interesting aspect of this is that competitive benchmarking will be more common with respect to data practices. Firms will need to be careful to ensure that their proprietary data is secure so that they can prevail the competitive advantages that t heir data is giving them. If they can, then they can gain first mover advantage for play that deliver incremental gains, or the complete overhaul of a system to take advantage of something gleaned from the data.References / whole kit CitedBoyd, D. Crawford, K. (2012). Critical questions for big data Provocations for a cultural, technological, and scholarly phenomenon. Information, confabulation and Society. 15 (5) 662-679.Chen, H., Chiang, R. Storey, V. (2012) air intelligence and analytics From big data to big impact. MIS Quarterly 36 (4) 1clxv-1188.Cooper, M. Ellram, L. (1993). Characteristics of supply chain management and the implications for purchasing and logistics strategy. transnational daybook of Logistics direction 4 (2) 13-24.Cooper, M., Lambert, D., Pagh, J. (1997). Supply chain management More than a new name for logistics. The supranational daybook of Logistics Management. 8 (1) 1-14.Demirkan, H. Delen, D. (2013) Leveraging the capabilities of service-ori ented decision support systems displace analytics and big data in cloud. finale Support Systems. 55 (2013) 412-421.Edelstein, S. (2016) Teslas autonomous-car efforts use big data no other carmaker has. Green simple machine Reports. Retrieved April 1, 2017 from http//www.greencarreports.com/news/1108065_teslas-autonomous-car-efforts-use-big-data-no-other-carmaker-hasFugate, B, Sahin, F. Mentzer, J. (2005) Supply chain management coordination mechanisms. University of Tennessee. https//www. seekgate.net/profile/Brian_Fugate/ publication/228349679_Supply_Chain_Management_Coordination_Mechanisms/links/0c96051e3eaaa0280f000000/Supply-Chain-Management-Coordination-Mechanisms.pdfHull, D. (2016) The Tesla advantage 1.3 billion miles of data. Bloomberg. Retrieved April 1, 2017 from https//www.bloomberg.com/news/articles/2016-12-20/the-tesla-advantage-1-3-billion-miles-of-dataHult, G., Ketchen, D. Slater, S. (2004). Information processing, knowledge development and strategic supply chai n performance. Academy of Management diary. 47 (2) 241-253.LaValle, S., Lesser, E., Shockley, R., Hopkins, M. Kruschwitz, N. (2010). Big data, analytics and the path from insights to value. MIT Sloan Management Review. http//sloanreview.mit.edu/article/big-data-analytics-and-the-path-from-insights-to-value/Lu, T., Guo, X., Xu, B., Zhao, L., Peng, Y., Yang, H. (2013). bordering big thing in big data The security of the ICT supply chain. IEEE figurer Society. Retrieved April 1, 2017 from http//diyhpl.us/nmz787/pdf/Next_Big_Think_in_Big_Data__the_Security_of_the_ICT_Supply_Chain.pdfMcAfee, A. Brynjolfsson, E. (2012). Big data The management revolution. Harvard business sector Review. Retrieved April 1, 2017 from http//www.rosebt.com/uploads/8/1/8/1/8181762/big_data_the_management_revolution.pdfProvost, F. Fawcett, T. (2013) Data science and its relationship to big data and data-driven decision-making. Big Data. 1 (1) 51-59.Tan, K., Zhan, Y., Ji, G., Ye, F. Chang, C. (2015) pro duce big data to enhance supply chain innovation capabilities An analytic infrastructure based on deduction graph. International Journal of Economics. 165 (2015) 223-233.Waller, M. Fawcett, S. (2013). Data science, prophetical analytics, and big data A revolution that will transform supply chain design and management. Journal of Business Logistics. 34 (2) 77-84.Wang, G., Gunasekaran, A., Ngai, E. Papadopoulos, T. (2016). Big data analytics in logistics and supply chain management Certain investigations for research and applications. International Journal of Production Economics. 176 (June 2016) 98-110.Zaslavsky, A., Perera, C. Georgakopoulos, D. (no date). perceptual experience as a service and big data. https//arxiv.org/ftp/arxiv/ cover/1301/1301.0159.pdf

Saturday, June 22, 2019

Human relationship and introduction to counseling Essay

Human relationship and introduction to counseling - Essay ExampleAccordingly, this analysis will be broken into six subsections which will be numbered accordingly and seek to answer key components of this authors communications model, the ways in which it has developed, and how a greater understanding of communications and communication theory abide help in ameliorating future breakdowns in interaction with key shareholders of given topics. Communication is essential in every interaction because it is through this process that an individual makes clear his/her thoughts and ideas. In health and companionable care, effective communication is necessary because there are certain conditions that greatly require the skill. For instance, for health caregivers, they should not respect competent be able to be patient in making the patients understand why they need to take in their medicines, rest at appointed periods of the daylight or do some exercise. They can do this by explanation bu t the fact is that, when one deals with a person who is in pain, they can easily get irritated and would refuse to listen and cooperate with the caregiver. Therefore, it has been suggested that people working in health and social care environments should be able to organize a conversation for effective communication. ... In addition, the caregiver should also understand cultural differences in order to understand what is being communicated by the patient and s/he would also know how to tell things to the patient. Asking questions is another skill that health and social care providers must be proficient in because they are able to bring out more necessary information about their clients through questioning (Lawrence 4). Lastly, they should also have listening skills, understanding what is said between the lines and not just grasping meanings from spoken words. There are indeed many facets of communication and these should be mastered for effective communication. As a function of ana lyzing the divergent means whereby communication takes place, and under what contexts/within which theories, this analysis will seek to briefly elaborate on the main categorizations of applicable theory and draw a level of inference upon the way in which models of communication can ultimately help in increasing the level and excellence of healthcare, as well as social care, to the end patient. Although it is not specifically the intent of this brief research to discuss the level to which communications within healthcare and social care can affect each and every shareholder, it is worth mentioning, and will be briefly discussed, the level to which communications ultimately leads to a clearer and more nuanced approach to healthcare and social care even within the healthcare community and the many shareholders this ultimately represents. Although the term communications encompasses a great many mechanisms, theories, and constructs, the term itself, with relation to healthcare and soc ial care can be simply defined as the process of

Thursday, June 20, 2019

Political Economy (Canada and the Global Political Economy) Essay - 4

Political Economy (Canada and the Global Political Economy) - Essay Exampleevident that, had those lessons been adopted most of the negative effects of the Global financial crisis of 2007 and 2008 would watch been avoided (Norton, 2010).The Bretton woodwind instrument system set out in the 1940s was synonymous with fixed exchange rates. As time passed and growth was evident in galore(postnominal) parts of the world, the system changed with market forces. The Bretton woods system encouraged growth in many countries of the world which and that encouraged expansions. On the same note, apart from lacquer all other industrialized countries had a managed inflation rate, lower interest rates and improved per capita income, few years after setting up of the Bretton institutions (Norton, 2010). term addressing whether lesson learnt from Bretton Woods systems would have worked for the global crisis, it is important to note that crises are usually worsened by contagion effect. The down fall of the Lehman Brothers had a verticillate effect. The most significant pointer to the collapse of the world economy during the global crisis of 2007/2008 was lapse in regulation. Most central banks were blamed for inapt leadership by failure to regulate despite the imminent economic imbalance. For example, the regulators failed in their role by allowing Lehman Brothers to go bankrupt. Due to that bankruptcy, many other add uping institutions panicked and refused to lend and that encouraged contagion that helped to spread the crisis further (Chornyy, 2011).Like the 2007/2008 global crisis, the Bretton woods system had challenges but the difference is evident in the manner in which the challenges were handled. For example, the Bretton woods system faced liquidity capers since the dollar was the fulcrum of the entire system and the USA which was biggest player in that regard had challenges. The Bretton system also faced a problem of adjustment. This was because most of the member c ountries took a considerable length of time to pay their debts. The most significant contributor to the

Wednesday, June 19, 2019

Women and Health Research Proposal Example | Topics and Well Written Essays - 2000 words

Women and Health - Research Proposal ExampleThis is complex study of different interrelated factors, as age merely does not stimulate towards aging diseases or undemocratic treatments. The major causes of higher mortality ratio of aging on women are cardiovascular diseases, such as flavor pellet, cancer particularly lungs and breast cancer, diabetics, and nutritional problems, such as obesity or anemic, arthritis, Alzheimers, mental illness leading to depression (Olds, London, & Ladewig, pp. 1-29), dementia, and sensory impairment, such as want of sight or hearing. Women have lower life expectancy in under developed countries than the developed due to various reasons such as uncomely nutrition, lack of access to healthcare, neglecting, and discrimination by the social society and mental anxiety etc. The important task is to determine the chronic ailment in women by their lifestyle, social and economic accordance, and perception of healthy lifestyle awareness that could increas e their expectancy ratio but aging still gives a square damage when the body starts to get ripened. They live few years more than their counterparts do but it is always engrave with sickness and disabilities (Bonita, pp. 2-25). Cardiovascular diseases mainly heart stroke is the highest and common cause of death in aged women than men. The older women are at a higher stake of heart attack and encircling(prenominal) arterial diseases since their entering into the postmenopausal period. INTRODUCTION The coronary heart diseases, such as heart attack, stroke, and other arterial vascular diseases are the angle of death for the aging women in the USA herby claiming approximately 2.3 million deaths due to heart attack and 0.87 million by the stroke. The death toll of cardiovascular diseases is six measure higher than widespread breast cancer in women. According to the statistics, almost 62% of older women struck by disability due to heart stroke and 36% are middle-aged women who surviv e the fatal heart attack (Bonita, pp. 2-25). Ab forbidden 58% of the women incur half of their health care bills on cardiovascular diseases. There will be an increase of 45% in the population of aged women suffering from coronary heart diseases by 2015 giving rise to the major health problem in near future. With the process of aging to 65, the risk of cardiovascular diseases toll to one in three and it will continue to sustain every year. The risk of lack of awareness in women of cardiovascular diseases after the advent of postmenopausal period is substantial and is the like the shield that have been wore out and exposed to the serious coronary disease which is a crucial cause of the study (Wenger et al., pp. 247-256). Risk Factors in uprising the Cardiovascular Diseases in Women The risk for underdeveloped the chronic coronary heart diseases are unlikely the same as their male counterpart. Smoking tobacco, hypertension, diabetics mellitus, high blood pressure, obesity, mal-nutrit ious life style, and exalted alcohol consumption, increased level of serum cholesterol, higher or lower density of lipo- protein levels (Olds, London, & Ladewig, pp. 401-440) and deprivation of estrogens hormones after the post menopause. Smoking cigarettes especially tobacco and nicotine consumption in younger women have raised by almost 23% since the last decade which is the major contribution to the chronic health diseases in the older age. Studies have also indicated that earlier in 1990s 45% of

Tuesday, June 18, 2019

The impact of divorce on human growth and development (childhood Research Paper

The impact of disunite on human growth and development (childhood through adulthood) - Research Paper role modelDivorce is veritably a family stressor that cripples the family system. Frequently, it causes chronic anxiety and the affected family members will be hard pressed to defuse the unbearable tension. An adolescent, who is susceptible, could be seriously affected by the crisis in the family. This development permits the quarreling parents to concent reckon on the pathology of the adolescent, thereby diverting attention from their private squabbles (Polacek, 2008, p. 10).The US experienced a drastic increase in the rate of divorce and separation, during the 1960s, 1970s and 1980s. During this time, there was an increase in the number of employed women. There was fluctuation in the relative contribution of spouses to the household income. Despite the wonderful amount of research conducted in this area, there is little understanding with regard to the effect of economic resourc es on marital dissolution (Sanz, 2007, p. iv).The impact of parental divorce on the development of children has been studied for more than three decades. Several research studies catch demonstrated an association amidst divorce and depression, diminished educational attainment, proto(prenominal) assumption of high risk conduct, and enhanced risk of suicidal behavior. In addition, marital discord is generally accompanied by depression. A number of family studies have shown that there is clear association between parental depression and negative child outcomes (Vousoura, et al., 2012, p. 718).In fact, Cummings and Davies have demonstrated a relationship between parental depression and depression in their children. In addition, parental depression has been seen to produce suicidal tendencies in children, anxiety disorders, dependence on intoxicants, somatic symptoms, dissipated behavior problems, insecure attachment, difficulty in controlling emotions, flawed psychosocial function ing, and problems related to attention and cognition (Vousoura, et al., 2012, p.

Monday, June 17, 2019

ARE HERBAL REMEDIES SAFE AND EFFECTIVE Research Paper - 1

ARE HERBAL REMEDIES SAFE AND EFFECTIVE - Research Paper ExampleA herbal remedy that relieves inflammation and pain called Chinese ululate God Vine weakens the immune system. The remedy is famous in for causing osteoporosis. Most of the herbs are ineffective unless their maintenance is in small quantities such as nutmeg and its cooking properties. When the nutmeg herbal is in large quantities, it cause liver failure and can at times lead to death.Many types of herbal remedies trace the shelves of health food stores and pharmacies. Most people consider that any drug having the label natural as effective and safe. Herbal remedies have been in humankind for a long time. Some of the remedies, even those carrying the natural label, can have serious and powerful negative drug effects in the body.The FDA regulates herbal supplements though not in the same manner it does with medicine of food. Herbal remedies form part of the dietary supplements. Regulations that apply to dietary supplemen ts are not strict as those of drugs and food. Manufacturers of herbal drugs, for example, do no need the approval of the FDA before availing them to the markets. When the herbal remedy gets to the market, it is the duty of FDA to ensure its safety. FDA, however, lacks the capacity and funding to check the standards of the many untried drugs. When FDA finds an herbal remedy that is not safe, it issues some requirements or orders to the distributor or manufacturer to remove it from the market (Harte 2-3).Soy provides dietary phytoestrogens that possess weak estrogenic activities. The soy herb treats menopausal symptoms and reduces the levels of cholesterol in the body. A review on the Soyas effectiveness was done on nine clinical trials to examine the impacts of increasing dietary soy. Nine more trials were done to determine the efficiency of Soy extracts. The review gave a conclusion that neither Soy extracts nor increase

Sunday, June 16, 2019

Management Principles and Application for Construction and the Built Essay - 1

Management Principles and Application for Construction and the Built Environment - Essay ExampleThe direction of reading tasks obliges learning of present day administration and additionally a comprehension of the design and construction process. Construction activities have a particular arrangement of tasks and objectives, for example, an item-by-item timeline for finishing. While the institutional courses of action or methodologies will vary, the management of such activities is much in a similar manner to the principles applied in business line management (Horlene & Randy, 2010). Construction show features that are present in a conventional business set up thus control in a similar way, as an enterprise organisation is possible. In most cases, the mission and the arrangement of tasks to be accomplished by the project recognize construction projects from the general rules of organizations. As indicated by the Project Management Institute, the arrangement of tasks and functional ities are dependent on the nature of the project and type of organisation employed. Construction project management is all about coordinating and facilitating human and material assets for the duration of the life of a task by utilizing current administration strategies to attain the planned targets of extension, expense, time, tonus and structural requirements (Hablot, 2011). By complexity, the general management of construction works and modern organizations expect a more extensive viewpoint with the more prominent rise of operations. In any case, there are sufficient likenesses and, in addition, contrasts between the two so that present day management procedures created for construction administration may require adjustments to fit the particular task.

Saturday, June 15, 2019

Combating compassion fatigue Assignment Example | Topics and Well Written Essays - 1500 words

Combating compassion fatigue - Assignment ExampleIn its entirety, compassion fatigue occurs when the caregiver carcass focused on processes of giving care to others that they fail to realize and provide care for themselves.Notably, most of the caregivers went into the practice with the hope of facilitating assistance to those in need. Additionally, the caregivers rely extensively on their compassionate capacity to manage the intensity of the work that comes with the profession. However, at times, the intensity of the various situations and life experiences that the caregivers encounter driving forces them vulnerable to the possibilities of suffering compassion fatigue. In its nature, compassion fatigue entails all the symptoms that the caregiver experience causing them to suffer from overwhelming exposure to physical and emotional stressors that leave them feeling traumatized as helpers (Ochberg & deliver from Within (Organization), 2012). The core causes of the cases of compassio n fatigue thus, entail the exposure to the stressors that cause their feelings and experiences face challenges in managing their actions. Notably, the encounter with the clients exposes the caregivers to various elements, which can significantly affect the cause of personal development of the caregiver. For instance, in a case where the caregiver is engaging with clients who suffer fears, pain, extreme suffering, intrusive thoughts, nightmares and hyper-vigilance they face aspects of cumulative stresses. The caregiver bares the suffering of such people, in addition, to that of their personal lives such as family and friend issues can result to significant buildup of extreme states of anxiety and preoccupation of such sufferings (Ochberg & Gift from Within (Organization), 2012). These developments progress to the causative agents of the situations where the caregivers suffer compassion fatigue. The caregivers suffer vicarious traumatization, which results in various aspects of emot ional, physical and

Friday, June 14, 2019

Employment loyalty at Rhythm Essay Example | Topics and Well Written Essays - 2750 words

Employment loyalty at Rhythm - Essay ExampleThus, the discussion down the stairs focuses on the more important results from statistical analysis of the survey data.The response rate to the survey consisted 37 percent in the 31-40 age-group, 30 percent in the 2130 age group, 27 percent within the 4150 age-group and seven percent in the over 50 age-group. Unfortunately, due to the disposition of the respondents country cultural constraints, all the respondents were males. A vast majority of the cohorts, 67 percent, were married with children and 27 percent were single, but seven percent of the respondents did not deport a response to the question intimately their marital status. Seven percent had a postgraduate masters degree as attributed to increased counterbalance of postgraduate level education in Saudi Arabia.A very significant proportion of the respondents included in the survey did not answer the questions about their area of expertise, job title and department worked at in Rhythm, and this was probably because of a fear of recognition in a company, which is not a menage with a very large issue of employees. Only twenty percent of the respondents were willing to share information about their total work experience and number of years at Rhythm as illustrated in Figure 4.1.5 and Figure 4.1.6. The longest serving employee at Rhythm had served for 15 years with the company later on having joined Rhythm with only one year of experience. However, because a vast majority of respondents did not answer the previously mentioned questions, it will be difficult to vomit up valid conclusions about stability of employment offered by Rhythm.Forty eight percent of Rhythm employees were deeply involved with their company and considered their organisations problems as their own, as illustrated in the figure below. This is a healthy ratio and the previously mentioned figure suggests a high degree of employee involvement in Rhythm.Only 26 percent of the respondents in dicated that they did not have a

Thursday, June 13, 2019

Open topic logos based argumentative paper Essay

Open topic logos based argumentative root word - Essay ExampleMost Congressmen admit to not have reading the Act before voting to pass it but those voting in esteem were overwhelming. Only one of 99 Senators (Wisconsin Senator Russ Feingold) and 66 of 423 Representatives voted against the rightfulness. The PATRIOT Act, as many citizens and legal experts alike have argued, violates the fundamental rights guaranteed by the U.S. Constitutions jump ten amendments, the Bill of Rights (Savage, 2006). This includes the freedom of speech and assembly (First Amendment) the freedom from unreasonable search and seizure (Fourth Amendment) the right to due process of law (Fifth Amendment) the right to a speedy, public and fair trial along with the right to counsel and to confront the accuser, (Sixth Amendment), the freedom from cruel and unusual punishment (Eighth Amendment) and freedom from punishment without conviction (13th Amendment). bingle of the most obvious tactics in the War on Terro r and the PATRIOT Act is the widespread use of racial profiling, described as when law enforcement officials use race, ethnicity, religion and even color of skin to de considerationine which persons are more probable to commit a crime such as terrorism. The term War on Terror has been continually invoked to justify breaches of the Constitution as well as the basic civil liberties of citizens and foreigners alike. The invocation of this phrase has repeatedly command rational discussions regarding civil injustices such as profiling individuals based on their race. Therefore racial profiling has continued unabated including the profiling of young dim men since September 11, 2001. The not-so-subtle insinuation is that one cannot condemn racial profiling because to do so will hinder the war on terrorism and undermine national security (McDonald, 2001).The popularly stated position is that racial profiling is necessary because not using this tool of law enforcement would compromise the effort against terrorism thus

Wednesday, June 12, 2019

Guess who's coming for dinner Essay Example | Topics and Well Written Essays - 1000 words

Guess whos coming for dinner - Essay ExampleThis was a historic ruling since before this time interracial wedding partys were outlawed in sixteen States. Notably, the film also brings out the generational divide linking parents of the duad, both from divers(prenominal) races. The interracial couple comprises Dr washstand Prentice, an African American doctor and Joanna Drayton, the daughter of two liberal parents- the father being a newspaper publisher and the mother a small art gallery owner. The couple met in Hawaii while Joanna was on holiday and fast one was attending a medical convention. Set in the home of the Draytons, the film unravels in this setting, as John is invited for dinner by Joanna, and later his parents show up. Considering themselves liberal, the Draytons are plagued with the predicament of approving their daughters marriage to a black man when John informs them he would cancel the engagement if they do not approve it. Parents from both sides acknowledge the stigma that would come upon their children if they choose to connect however, when Johns parents arrive, a Joannas and Johns mother come to an understanding and approves the marriage. In this instance, the fathers are still adamant on the impracticality of such a union. The film reaches its sexual climax when Matt Drayton, Joannas father, announces his approval since love surpasses all. The film takes a dramatic turn when Matilda Banks, fondly known as Tillie opposes greatly the marriage of Joanna and John. Tillie has been the house-help of the Draytons for over 20 years, having raised Joanna and therefore feels inclined to express her precaution over her marriage to a black man despite the fact that she is black too. Throughout the film, fear and prejudice are the two things that ail society, including even the most liberal of people- the Draytons. This is because they are afraid the world leave shun their daughter for her choice of marriage partner. Moreover, Tillie is prejudi ced towards white people as she feels they say one thing out in the open but act in a different manner when they are in closed quarters. Furthermore, she understands the stereotype of black peoples inferiority by stating that John was getting ahead of himself by not only being a brilliant doctor, but also falling in love with a white woman. However, John defends his father his decision to marry Joanna, amid all the prejudices, he states that his father had to transport mail for such long distances in order to encourage him, as it is his responsibility as the person that brought him to earth. John declares that if he were to get a son, he would have the same responsibility. This depiction implies that a parents role lies fundamentally in upbringing and support however, it does not afford the parent the right to dictate the childs decisions. This is why John unwaveringly states he owes his father nothing and his decision will not be faltered. This is hypocritical as he is willing to cancel the engagement if Joannas father disapproves but he will not do the same if his father disapproves. Stanley Kramer, the producer of the film, received accolade for the film as it addressed a vital topic in society relating to the segregation surrounded by blacks and whites that had long persisted in America. The film was a revolutionary as it confronted racism from a societal point of view this is because

Tuesday, June 11, 2019

Leadership Essay Example | Topics and Well Written Essays - 1500 words

Leadership - Essay ExampleThe Executive Maturity model is based on the idea that the attractor should be able to respond effectively to the require of others under pressure (Trathen 2007). The above model incorporates two key phases in the first phase, the leader needs to be aware of his own feelings, thoughts and values (Trathen 2007, p.71). In the spot phase, the leader has to manage the emotional needs of others (Trathen 2007, p.71), keeping a balance. On the other hand, horse parsley (2008) notes that the key characteristic of a successful leader would be his ability to handle crises and mitigate effects (Alexander 2008, p.34). Cooper (2010) notes that the identification of a leaders competencies is necessary before trying to improve the leaders effectiveness. After re earning my leadership strengths and weaknesses, as presented in the previous section, I would come to the discovering death I should emphasize more on decreasing the time I need for managing complex tasks, so that I would become more efficient in a range of projects I should continue focusing on details but I would try to limit the time spent on issues of unessential importance. The Executive Maturity model would help me to change my leadership style, setting appropriate priorities and increasing collaboration. Question 2 Are leaders born or made? Each leader has unique characteristics, even if the particular fact is not clear. Indeed, the leadership style is closely related to the personality of each unmarried and from this point of view it would be quite difficult to identify two leaders that would respond exactly the same to a series of critical events. Yuki (1988) go through noted that leadership effectiveness varies across situations (Yuki 1988, cited in... The researcher of this essay discusses the topic of leadership that today is a concept that can incorporate a proud range of characteristics. Observing several responses to various challenges, the researcher could identify th e strengths and weaknesses of several leaders. Referring to his own leadership strengths and weaknesses, the researcher would highlight the following issues I am move to my studies, trying to respond to all the demands of my position. I have always tried to examine thoroughly the requirements of every task assigned to me, focusing on details. In case of mistakes or failures Ive been able to respond immediately, suggesting appropriate plans of action. On the other hand, I have often failed in identifying early the risks related to a particular task.. Then , the researcher states that The Executive Maturity model would help him to change his leadership style, setting appropriate priorities and increasing collaboration. On the discussion of the second question Are leaders born or made?, the researcher states that from his point of view, leadership is both inherited and learned, a view aligned with the view of Larkin. Then, the researcher discusses the differences between leadership & management. In summary, it could be stated that leadership focuses on establishing and promoting the practices that will enhance the performance of organization. Management aims to ensure that employees will follow the guidelines of the leader so that the targets set are achieved.

Monday, June 10, 2019

China's Air pollution Term Paper Example | Topics and Well Written Essays - 3000 words

chinawares Air pollution - Term Paper ExampleIn this situation, China is faced with a major debate. The solid ground is one of the highest contributors of environmental pollution particularly the bare. The air is an important part of human life and it is an naturalised belief that the microscopic particles that people inhale while breathing can potentially cause serious damage to their health. The amount of damage is dependent on the level of concentration of pollutants in the air. These pollutants argon emitted in to the environment through various industrial and economic activities, which in turn increases the concentration level of pollutants in the air. There are a number of factors that affect the relationship between emission of pollutants and their concentration in the air. However, it is a commonly agreed notion that the emissions are an outcome of increased level of industrial activities in the economy, or in other words, the level of development activities that take pla ce in the economy (Matus, et al., wellness Damages from Air Pollution in China). Among the factors affecting the level of pollution in the air, site is very important. Certain places are the key acknowledgment of emission such as the center of the cities, and exclusive industrial belts. These areas are most populous increased proximity to these regions affects meteorological conditions more than the other areas in the state of matter, which in turn determines the extent of environmental damage. Secondly, the characteristics of the source such as the emission temperature and the velocity of emission affect the rate at which level of air pollution increases. Thirdly, physical dimension of the pollutant particles interferes in the level of impact cast on health condition of human beings. Hence the particle size of return is an important factor in determining air pollution in the country. Not only are the humans sufferers of this environmental condition, other animals are overly adv ersely affected in this environmental degradation (Ho, Air pollution in China). The Economic reform Chinas economy has been reflecting coarse growth rates since the past two decades. During this period China has undergone economic reforms and is now considered one of the worlds fastest growing economies. The per capita income of the citizens in the country has been growing at the astonishing rate of 9% in 2011 (Mendez, Chinese Economic Development and Pollution). China has been ranked as the third largest country that take part in the international trade. It comes immediately after United States of America and Japan. This economic reform in the country is the main reason that has pushed China to the position in the international sphere. Increasing importance of the economy in world trade has transformed the economy into a global powerhouse. There has been issuance of new factories and overall rate of productive activities in the country has rocketed. These industries obtain their primary supply of energy from the reserves of coal possessed by China. push is produced by burning this coal, which emits huge amount of carbon particles in the air. This implies that urbanization and development of the Chinese economy has also led it on the path of make significant contribution towards degradation of the environment.

Sunday, June 9, 2019

Macroeconomic Essay Example | Topics and Well Written Essays - 1250 words

Macroeconomic - Essay ExampleInternational business is at its zenith when almost all the economies in the globe are open. Business cycles fluctuations are common to almost all the economies in the modern world. This essay will through with(predicate) light on the Global Financial Crisis that had taken place in 2007-2008. The essay will discuss the impacts created by this financial crisis on different economies in the world. This part of the essay will concentrate on the growth of real Gross Domestic Product, splashiness rate and unemployment rate in Australia, unify States and united Kingdom. Answer 1 Figure 1 Real gross domestic product, Unemployment, and Inflation Rates of U.S. (Source ABS, 2013 BLS, 2012) The above graph shows the real GDP, inflation rate and unemployment rate in United States. Figure 2 Real GDP, Inflation and Unemployment of Australia (Source DFAT, 2013 RBA, 2013) The above graph shows the real GDP, inflation rate and unemployment rate in Australia. Figure 3 Real GDP, inflation and Unemployment in United Kingdom (Source DFAT, 2013 BEA, 2012) The above graph shows the real GDP, inflation rate and unemployment rate in United Kingdom. Answer 2 The above iii line graphs show that global crisis has negatively affected all the three economies in the world. It is clearly visible that due to recession in 2007 to 2008, the real GDP of all the three economies has shown a sharp happen upon in 2008, 2009 and 2010. The recessionary trails in the economy were responsible for the low velocity of circulation of money in the economy. With fall in purchasing powers, the aggregate subscribe for goods and services has been low in the three nations. Thus, although there has been an overall growth in real GDP barely the global financial crisis has lead to a fall in GDP in the short run. The crisis in the economy has reduced both the income and output levels. As a result, the unemployment rates have also augmented. Economic crisis is often associated with inflationary trails in the economy. Scarcity causes price rise in almost all the goods and services. However, with eon all these three developed economies are recovering from the extreme crisis. Answer 3 A nation must always formulate policies of growth in a way that helps it to use the benefits of its core competences. In the modern era almost all the countries in the world are open economies. International carry on is at its peak. At this juncture it is always advisable for a nation to produce only those goods and services, over which they have competitive advantages. This would help the nation to deal its resources in an efficient method. While making resource allocations, the state as well as the business enterprises will always find the stock of resources to be scarce, when compared to the demand in the economy. The country in Africa is a labour surplus nation, then the public as well as the private sectors should stress on labour intensive methods of production. However, th at does not mean that the nation would not undertake technological inventions. The state should adopt capital intensive techniques but not at the cost of its labour requirements. Maintaining the labour concentrated methods of production, both public and private sectors of the country would be able to generate more employment for people. A higher(prenominal) employment will increase both income and purchasing power of the people in the country that would ultimately help in raising the aggregate demand of the nation. Rise in aggregate demand will finally help in augmenting the GDP of the country. For economic development, technological inventions are always in extend with depletion of national resources. Thus, the government of the country must adopt sustainable technological improvements to protect the rich natural reserves of the nation. As the country concerned has a free or Laissez faire economy, the government should not make unnecessary interventions in the matters of economic affairs because that would involve a fall in the net brotherly welfare. Free forces of market demand and supply should be allowed to set most of the price levels

Saturday, June 8, 2019

Raising children can be stresful Research Proposal

Raising children can be stresful - Research Proposal drillIs p atomic number 18nting stressful or rewarding? Do you have the joy of parenthood? Or does parenthood leaves you with shattered dreams? Parenting is a heroic act and can be very stressful. You may be a stay at home or a working parent, single or married parent, mother or father, with one or several children, if you remain to stay cool, calm, and with full of vigor, you will be able get through the day (Child Development Institute, 2007).Children can be stubborn, grumpy, sensitive, angry, manipulative, wild or simply plain difficult. They always thought no other but themselves and they have an unpredictable temperament that oftentimes leaves you at a loss (Perry, 2008). The attitudes of your children leave you stressed and desolated. However, most of the time, it is on how we label our children makes parenting stressful.When a situation a parent should have with the child cannot be controlled, it is necessary that an gran t approach on how to cope with the stress you have with your child should be embraced (Perry, 2008). These are (1) Teaching your children limits and healthy self - expression (2) model problem - puzzle out strategies (3) empathize with your children (4) breakdown challenges into smaller steps (5) project confidence in your child (6) shape good, mature behavior, and (7) seek professional help.To avoid having violent and stressful environment with your child, it is important that the following must be observed (1) offer your children the love and attention that he needs consistently (2) make sure that your children are properly supervised (3) show appropriate behavior to your children by the way you act (4) do not apply physical punishments (5) stick to your rules and disciplines (6) teach your children astir(predicate) the dangers of firearms (7) keep them away from violence (APA Online, 2008).Like adults, children also need to have love, care, attention, and

Friday, June 7, 2019

Ap Biology Notes Cellular Communication Essay Example for Free

Ap Biology Notes Cellular Communication EssayCell-to- cadre communication is essential in multi cellph cardinalular organisms. They must communicate to coordinate typifyivities such as proceeds and development, and reproduction. In addition unicellular organisms communicate with each separate. Signals may use light, or touch but we will focus on chemical point outs.1. orthogonal signals are converted to responses within the cell a. Evolution of cell intercommunicate i. In barm a cells and cells both secrete chemicals, which butt totally be received by the alternate type yeast. This signals the two cells to join via fusion 1. The process by which the signal on the surface of the cell is converted to a series of steps by the cell in response is called a signal transduction pathway ii. Signal transduction pathways are very similar in yeast and in complex multicellular organisms 2. This leads scientists to believe that this pathway evolved first in ancient prokaryotes b. Lo cal and long distance polarity iii. Local signaling3. neighboring cells of plants and animals may communicate through cell junctions a. Signaling substances dissolved in the cytoplasm travel between cells i. Plants = plasmodesmataii. Animals = gap junctions4. Animal cells may use the side by side(p)b. Cell-to-cell recognitioniii. Direct contact between membrane-bound cell-surface molecules iv. Important in embryonic development and immune responsec. Paracrine signalingv. Uses local regulators which are released and travel only a short distance to nearby cells vi. Ex. Growth factors coffin nail nearby cells to grow and divide d. Synaptic signalingvii. Electrical signal along a nerve cell triggers a chemical release across a synapse to trigger response in target cell viii.Ex. Nerve cellsiv. Long- distance signaling5. Both plants and animals use hormonese. Animals (endocrine signaling) cells release hormones which travel in the circulatory system to target cells f. Plants hormones travel in vessels or by diffusion through the g grim as gas g. Hormones vary in size and traffic pattern6. Nervous system signals can also be long distance c. The three stages of cell signaling A previewv. Reception when the target cell detects a signaling molecule. The signaling molecule binds to a receptor protein on the target cells surface vi. Transduction After binding the receptor protein is changed in some way, this converts the signal to a form that will bring about a unique(predicate) cellular response7. May occur in a single step or a series of changes vii. Response The transduced signal triggers a specific cellular response. 8. Catalysis of an enzyme, rearrangement of the cytoskeleton, activation of a specific gene 2. Reception A signaling molecule binds to a receptor protein, causing it to change shape d. To ensure signals are sent to the correct cell signaling molecules act as a ligand. viii. Ligand- molecule that specifically binds to another (usually larger) molec ule ix. The receptor protein thence usually changes shape x. May be located on the membrane or inside the cell e. Receptors in the plasma membranexi. Water-soluble signaling molecule binds to receptor on the membrane causing it to change shape or aggregate. f. Intracellular Receptors xii. Found in cytoplasm or nucleus of target cells9. Signaling molecule must be hydrophobic enough or small enough to pass through the plasma membrane h. Steroid hormones, thyroidal hormones, nitric oxide Examples Pathway OtherG-Protein Coupled Receptors Yeast junction factors, epinephrine, hormones, neurotransmitters 1. signaling molecule binds to the g-protein receptor 2. receptor changes shape and the cytoplasmic side binds to the inactive G protein 3. GTP then displaces to form GDP and activates the protein 4. Activated G protein diffuses along the membrane to an enzyme altering the enzyme to trigger the next step Bacteria such as whooping cough, botulism and epidemic cholera disrupt this pathwa y Receptor Tyrosine Kinases Enzymes that catalyze the transfer of phosphate groups 1. binding of two signaling molecules to two tyrosine chains causes the two to associate with each other forming a dimer2. dimerization activates the tyrosine kinase region to add a phosphate from and ATP to each tyrosine in the polypeptide 3. each tail can now bind to and activate a different specific relay protein within the cell One receptor may activate ten+ pathways. Absence can result in pubic louse Ion Channel Receptors Nervous system 1. signaling molecule binds to the ion get in the membrane 2. protein changes shape creating a channel through the membrane 3. specific ions can now flow through the membrane which may cause a change in the cell or trigger another pathway most ion gated channels are controlled by change in voltage rather than binding of a ligandg. Intracellular Receptorsxiii. Ex. Testosterone10. Hormone passes through the plasma membrane 11. Testosterone binds to a receptor pro tein in the cytoplasm activating it 12. The hormone-receptor complex enters the nucleus and binds to a specific gene 13. The bound protein acts as a arrangement factor, stimulating the transcription of the gene into mRNA 14. The mRNA is translated into a specific protein 3. Transduction cascades of molecular interactions relay signals from receptor to target molecules in the cell h. Protein phosphorylation and dephosphorylationxiv. Proteins can be trigger by the addition of a phosphate group (often broken off of ATP or GTP) 15. Phosphates are transferred from ATP to a protein by a global group of enzymes known as protein kinases i. Phosphorylation often causes the protein to change shape j. This happens because the added phosphate group interacts with polar or charged amino acids within the protein xv. Protein phosphatases are enzymes that sequestrate phosphate groups from a protein 16. Mechanism for turning off signal transduction 17. These also allow for turning off and reusin g pathways i. Small molecules and ions as second messengersxvi. Molecules other than proteins act as second messengers 18. Small and water soluble such as ionsk. This allows them to rapidly spread throughout the cell via diffusion 19. Second messenger refers to anything by and by the first messenger which is the extracellular signaling molecule that binds to the membrane 20. Most common second messengers are cyclic AMP and Ca+2 xvii. cyclic AMP as a second messenger in response to the hormone epinephrine 21. Epinephrine binds to receptor molecule protein activates adenylyl cyclase which can catalyze the implication of many molecules of cAMP l. Adenylyl cyclase catalyzes the conversion of ATP into cAMP ix. cAMP usually activates a serine/threonine kinase known as protein kinase A which phosphorylates many other proteins m. cAMP is converted back to AMP by phosphodiesterase xviii. Calcium ions and inositol tripohosphate22. Increasing calcium concentration causes responses such as m uscle contraction, secretion of substances, and cell division in animals, and discolor in response to light in plants 23. Calcium is usually in high concentrations outside of the cell and in the ER but in low concentrations in the cytosol 24. Pathwayn. Signaling molecule binds to receptor o. Phospholipid pinches off membrane IP3 is released as second messenger p. IP3 binds to receptor on ER causing protein channel to open q. Ca+2 is released into cytosol4. Response Cell signaling leads to regulation of transcription or cytoplasmic activities j. Nuclear and cytoplasmic responsesxix. Pathways lead to the regulation of one or more cellular activities25. Regulate protein synthesisr. Turning specific genes on or off (calls for the synthesis of mRNA from DNA)26. Regulate protein activitys. drive a shape change to turn a protein on or off27. Regulate overall shape change of cell28. Release of mating factors29. Cell divisionk. Fine-tuning of the responsexx. Signal amplification30. Enzyme cascades amplify effects by increasing the product at each step t. Enzymes sting active long enough to work on multiple products before becoming inactive xxi. The specificity of cell signaling and coordination of the response 31. Different types of cells are programmed to reply to only certain types of signals u. Some cells will respond to the same signals but in different ways v. This is because different cells have different collections of proteins xxii. Signaling cogency scaffolding proteins and signaling complexes32. Scaffolding proteins increase the efficiency of the response w. A large protein with multiple protein kinases attached x. Decreases the time of the response because diffusion between proteins is not needed 33. Pathways are not linear, in fact the same protein may act in multiple pathways 34. Relay proteins serve as branch points where the signal may go in one of two directions xxiii. Termination of the signal35. Each step in the pathway lasts only a short time, t his makes the proteins arrange for a new signal 36. When the signaling molecule leaves leave the receptor it reverts to its inactive form and the relay molecules follow